diff --git a/.changeset/dry-readers-itch.md b/.changeset/dry-readers-itch.md
new file mode 100644
index 000000000..69b5600fe
--- /dev/null
+++ b/.changeset/dry-readers-itch.md
@@ -0,0 +1,5 @@
+---
+"@uppy/tus": patch
+---
+
+Fix Node.js support by conditionally setting a property which does not exist in Node.js instead of crashing.
diff --git a/packages/@uppy/tus/src/index.ts b/packages/@uppy/tus/src/index.ts
index afd30f756..95cf1bb19 100644
--- a/packages/@uppy/tus/src/index.ts
+++ b/packages/@uppy/tus/src/index.ts
@@ -251,7 +251,9 @@ export default class Tus<M extends Meta, B extends Body> extends BasePlugin<
 
       uploadOptions.onBeforeRequest = async (req) => {
         const xhr = req.getUnderlyingObject()
-        xhr.withCredentials = !!opts.withCredentials
+        if (xhr) {
+          xhr.withCredentials = !!opts.withCredentials
+        }
 
         let userProvidedPromise: Promise<void> | void
         if (typeof onBeforeRequest === 'function') {